Curtin University researchers have shown natural radioactivity within DNA can alter chemical compounds, providing a new pathway for genetic mutation.<\/p>\n
The research, recently published in Biochimica et Biophysica Acta-General Subjects, <\/i>for the first time looked at natural radioactivity within human DNA on the atomic-scale.<\/p>\n
While radioactivity occurs naturally in our bodies as well as in every living organism across the planet, it was never before thought to affect our DNA in such a direct way.<\/p>\n
Using high-performance computers, the research team from Curtin and Los Alamos National Laboratory were able to show radioactivity could alter molecular structures which encode genetic information, creating new molecules that do not belong to the four-letter alphabet of DNA.<\/p>\n
Professor Nigel Marks from Curtin\u2019s Discipline of Physics and Astronomy and Curtin\u2019s Nanochemistry Research Institute said the new molecules may well generate mutations by confusing the replication mechanisms in DNA.<\/p>\n
\u201cThis work takes an entirely new direction on research into natural radioactivity in biology and raises important questions about genetic mutation,\u201d Professor Marks said.<\/p>\n
\u201cWe have discovered a subtle process that could easily be overlooked by the standard cell repair mechanisms in the body, potentially creating a new pathway for mutations to occur.\u201d<\/p>\n
Professor Marks said the work was both exciting and unexpected, emerging as a spin-off from an Australian Research Council funded project on nuclear waste.<\/p>\n
\u201cAs part of the project between Curtin and Los Alamos we developed a suite of computational tools to examine deliberate radioactivity in crystalline solids, only to later realise that the same methods could be applied to natural radioactivity in molecules,\u201d he said.<\/p>\n
\u201cThis direction was an unplanned outcome of our research program \u2013 just the way blue skies research should be.\u201d<\/p>\n
The natural radioactivity in focus involved the decay of carbon atoms, Carbon-14, turning into nitrogen atoms, Nitrogen-14.<\/p>\n
Professor Marks said this was one of the most abundant forms of radioactive decay occurring in biological systems. Over a human lifetime, around 50 billion Carbon-14 decays occur within our DNA.<\/p>\n
\u201cWhile it is still not obvious how DNA replication is affected by the presence of chemical compounds that are different to the four-letter alphabet of DNA, it is quite remarkable to consider that Carbon-14 could be a source of genetic mutation that would be impossible to avoid due to the universal presence of radiocarbon in the environment,\u201d Professor Marks said.<\/p>\n